William Wulff
Research
Synthetic Organic Chemistry
Wulff Group Research is concentrated in the area of organic synthesis and catalysis. We are motivated by the pursuit of novel approaches in synthetic organic chemistry involving design and development of new asymmetric organocatalysis, organometallic chemistry, mechanistic studies and total synthesis of natural products.
Research Field Highlights
1) New Enantioselective Organocatalysis
2) Fischer Carbene Chemistry
3) Mechanistic Investigations on Organocatalysis
4) Total Synthesis of Natural Products
Area(s) of Interest
Organic (Or)
Organometallic (Om)
Selected Publications
Self-Assembly of a Library of Polyborate Chiral Anions for Asymmetric Catalysis, Desai, A. A.; Vetticatt, M. J.; Guan, Y.; Odom, A. L.; Majumder, S.; Wulff, W. D. Tetrahedron Lett. 2015, 56, 3481.
Catalytic Synthesis of 2H-Chromenes, Majumder, N.; Paul, N. D.; Mandal, S.; de Bruin, B.; Wulff, W. D., ACS Catalysis 2015, 5, 2329-2366.
The Nature of Meso- and Pyro-borate Precatalysts to the VANOL and VAPOL BOROX catalysts, Zhao, W.; Yin, X.; Gupta, A. K.; Zhang, X.; Wulff, W. D., Synlett 2015, 26, 1606-1614.
Catalyst Controlled Multi-Component Aziridinatons of Chiral Aldehydes, Mukherjee, M.; Zhou, Y.; Dai, Y.; Gupta, A. K.; Reddy, V. R.; Staples, R. J.; Wulff, W. D., Chem. Eur. J. 2017, 23, 2552-2556.
Enantioselective Palladium-Catalyzed Carbonylative Carbocyclization of Enallenes via Cross-Dehydrogenative coupling (CDC) with Terminal Alkynes: An Efficient Construction of α-Chirality of Ketones, Yang, B.; Qiu, Y.; Jiang, T.; Wulff, W. D.; Yin, X.; Zhu, C.; Backvall, J.-E., Angew. Chem. Int. Ed. 2017, 56, 4535-4539.
Multi-Component Cis- and Trans-Aziridinations in the Syntheses of all Four Stereoisomers of Sphinganine, Zhou, Y.; Mukherjee, M.; Gupta, A. K.; Wulff, W. D., Org. Lett. 2017, 19, 2230-2233.
Pyro-borates, Spiro-borates and Boroxinates of BINOL – Assembly, Structures and Reactivity, Hu, G.; Gupta, A. K.; Huang, L.; Zhao, W.; Yin, X.; Osminski, W. E. G.; Huang, R. H.; Wulff, W. D; Izzo, J. A.; Vetticatt, M. J., J. Am. Chem. Soc. 2017, 139, 10267-10285.
Multi-Component Catalytic Asymmetric Synthesis of Trans-Aziridines, Zhou, Y.; Gupta, A. K.; Mukherjee, M.; Zheng, L.; Wulff, W. D. J. Org. Chem. 2017, 82, 13121-13140.
Catalytic Asymmetric Epoxidation of Aldehydes with Two VANOL-Derived Chiral Borate Catalysts, Gupta, A.K.; Yin, X.; Mukherjee, M.; Desai, A.A.; Mohammadlou, A.; Jurewicz, K.; Wulff, W.D., Angew. Chem. Int. Ed. 2019, 58, 3361.
CV
B.S., 1971, Univ. of Wisconsin-Eau Claire
Ph.D., 1979, Iowa State Univ.
NIH Postdoctoral Fellow, 1979-80, Princeton Univ.
Awards/Honors
| Year | Award | Organization |
|---|---|---|
| 2013 | CNS Distinguished Faculty Award | |
| 1999 | Professor | Michigan State University |
| 1998 | Fellow | American Association for the Advancement of Science |
| 1992 - 1999 | Professor | The University of Chicago |
| 1986 - 1992 | Associate Professor | The University of Chicago |
| 1986 - 1987 | Young Scholar Award | Eli Lilly |
| 1980 | Assistant Professor | The University of Chicago |
| 1979 - 1980 | Postdoctoral Fellowship | National Institutes of Health |
| 1979 | Ph.D. | Iowa State University |
| 1979 - 1980 | Postdoctoral Fellow | Princeton University with Professor M.F. Semmelhack |
| 1979 - 1980 | NIH Postdoctoral Fellow | National Institutes of Health |
| 1974 - 1979 | Research Assistant | Iowa State University with Professor T.J. Barton |
| 1972 - 1974 | Laboratory Technician | Saint Agnes Hospital (Baltimore, Maryland) |
| 1972 - 1974 | Laboratory Technician | 1st United States Army Medical Laboratory (Fort Meade, Maryland) |
| 1972 | Microwave radio repair | United States Army Signal Corps (Fort Monmouth, New Jersey) |
| 1971 | Bachelor of Science | University of Wisconsin-Eau Claire |
| 1968 - 1971 | Research Assistant | University of Wisconsin-Eau Claire with Professor L.G. Schnack |
| Member | American Chemical Society | |
| Member | Chemical Society (London) |